Spinal interneurone depression by DS103-282.
نویسندگان
چکیده
The depressant effect of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiodiazole (DS103-282) on the polysynaptic excitation of interneurones in the cat spinal cord appears to be related to a postsynaptic reduction in the effectiveness of excitatory transmitters than to interference with their presynaptic release.
منابع مشابه
The assessment of drug treatment of spastic gait.
The technique of polarised light goniometry was used to quantify objectively parameters of the spastic gait during a double-blind cross-over trial comparing the spasmolytic effects of DS103-282, baclofen and placebo. Only minimal objective and subjective changes in gait were found when the results of treatment with DS103-282 or baclofen were compared with those of treatment with placebo.
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ورودعنوان ژورنال:
- British journal of pharmacology
دوره 79 1 شماره
صفحات -
تاریخ انتشار 1983